Alexandra Fraser, the co-CEO of Maverick, is leaving the UK producer after almost two decades.
Maverick is best known as the producer of Embarrassing Bodies and is owned by UK super indie All3Media.
Fraser said she will explore new opportunities, while also taking a consultancy role with All3Media.
Her co-CEO Jim Sawyer will take full control of the company following her departure. Other changes at the company include Mark Downie being upped from head of factual to chief creative officer and development boss Paul Woolf upped to director of development.